Professor Onishi Motoko from the Department of Applied Biochemistry, Department of Applied Biology, Chubu University, Japan, and others cooperated with San-ei Sucrochemical, a saccharified product company that produces glucose and other saccharification products, and found through human clinical trials that indigestible oligosaccharides possess both sugar and acid properties. "Maltobionsyre" inhibits the loss of collagen components in bones and helps maintain bone components.
About five years ago, the research team looked at the "maltonic acid" contained in honey, which people have been eating since ancient times, and evaluated its effect on maintaining bone health. In the evaluation experiment, the research team first performed cell experiments using bone marrow cells collected from mouse femurs and found that adding maltonic acid to the cells inhibited osteoclast differentiation. Then, animal experiments were conducted, and after feeding the ovariectomized postmenopausal model mice with a diet containing maltonic acid for 80 consecutive days, it was confirmed that calcium loss and bone density in the femur were significantly suppressed compared with mice fed a diet without maltonic acid. decline.
For at verificere effekten på den menneskelige krop blev der også udført et klinisk forsøg med mennesker, hvor kvindelige ansatte i 40'erne til 60'erne ved Chubu University indtog 4 g granulat indeholdende maltonsyre om dagen i 4 på hinanden følgende uger. Resultaterne viste, at udskillelsen af knogle-afledte kollagenkomponenter (DPD, u-NTx, indikatorer for knogleresorption) i urinen fra 33 menopausale mænd i mere end 1 år var signifikant reduceret sammenlignet med før indtagelse af maltonsyre. , hæmmede vedvarende indtag af maltonsyre knogletab. Derudover er maltonsyre et ufordøjeligt oligosaccharid, så dette kliniske forsøg bekræftede, at maltonsyre også har effekten af at forbedre afføringsmidler og regulere mave-tarmtilstanden.
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